NEW YORK (Reuters Health) - An extended-release version of the anti-addiction medicine naltrexone reduces drinking in alcohol-dependent patients within two days of being injected, according to a new study.
Naltrexone blocks opioid receptors and is approved for use in alcohol-dependent patients. To improve adherence, "an intramuscular, injectable, extended-release formulation of naltrexone has been developed," Dr. Domenic A. Ciraulo, of Boston University School of Medicine, and colleagues explain in the Journal of Clinical Psychiatry.
The researchers tested injectable naltrexone XR in some 600 actively drinking, alcohol-dependent men and women who were given one of two doses of the drug or an inactive placebo every 4 weeks for 24 weeks. The participants also received 12 sessions of standardized, low-intensity psychosocial therapy.
Compared with the placebo patients, patients given the higher dose of naltrexone had a significant reduction in the average daily number of drinks consumed by the second day. By the third day, fewer naltrexone patients reported heavy drinking compared with those on placebo (20 percent versus 35 percent, respectively). This reduction was maintained throughout the study.
While patients treated with the lower dose of naltrexone XR experienced reductions in these measures, the differences compared with placebo were not statistically significant.
Ciraulo's team is encouraged by the results. "Potential clinical implications of the rapid, early onset of effect of this medication's delivery system for patients who are dependent on alcohol include facilitation of early engagement in treatment, motivation to continue treatment, and focus on the goals established in counseling," they write.
SOURCE: Journal of Clinical Psychiatry, February 2008.
Showing posts with label medicine. Show all posts
Showing posts with label medicine. Show all posts
Friday, March 21, 2008
Wednesday, January 2, 2008
Minorities less likely to get narcotics for pain
CHICAGO (AP) — Emergency-room doctors are prescribing strong narcotics more often to patients who complain of pain, but minorities are less likely to get them than whites, a study finds.
Even for the severe pain of kidney stones, minorities were prescribed narcotics such as oxycodone and morphine less frequently than whites.
The analysis of more than 150,000 emergency-room visits over 13 years found differences in prescribing by race in both urban and rural hospitals, in all U.S. regions and for every type of pain.
"The gaps between whites and nonwhites have not appeared to close at all," said study co-author Dr. Mark Pletcher of the University of California at San Francisco.
The study appears in today"s Journal of the American Medical Association. Prescribing narcotics for pain in emergency rooms rose during the study, from 23 percent of those complaining of pain in 1993 to 37 percent in 2005.
The increase coincided with changing attitudes among doctors who now regard pain management as a key to healing. Doctors in accredited hospitals must ask patients about pain, just as they monitor vital signs such as temperature and pulse.
Even with the increase, the racial gap endured. Linda Simoni-Wastila of the University of Maryland at Baltimore's School of Pharmacy said the race-gap finding may reveal some doctors' suspicions that minority patients could be drug abusers lying about pain to get narcotics.
The irony, she said, is that blacks are the least likely group to abuse prescription drugs. Hispanics are becoming as likely as whites to abuse prescription opioids and stimulants, according to her research. She was not involved in the current study.
In the study, opioid narcotics were prescribed in 31 percent of the pain-related visits involving whites, 28 percent for Asians, 24 percent for Hispanics and 23 percent for blacks.
Minorities were slightly more likely than whites to get aspirin, ibuprofen and similar drugs for pain.
The study's authors said doctors may be less likely to see signs of painkiller abuse in white patients, or they may be undertreating pain in minority patients.
Patient behavior may play a role, Dr. Pletcher said. Minority patients "may be less likely to keep complaining about their pain or feel they deserve good pain control," he said.
Stricter protocols for prescribing narcotics may help close the gap.
A New York hospital recently studied its emergency patients and found no racial disparity in narcotics prescribed for broken bones. Montefiore Medical Center aggressively treats pain and is developing protocols for painkillers that dictate initial dosages and times to check with patients to determine whether they need more pain medicine, said Dr. David Esses, emergency department associate director at Montefiore.
Such standards may eliminate racial disparities, Dr. Esses said.
source: The Washington Times
Even for the severe pain of kidney stones, minorities were prescribed narcotics such as oxycodone and morphine less frequently than whites.
The analysis of more than 150,000 emergency-room visits over 13 years found differences in prescribing by race in both urban and rural hospitals, in all U.S. regions and for every type of pain.
"The gaps between whites and nonwhites have not appeared to close at all," said study co-author Dr. Mark Pletcher of the University of California at San Francisco.
The study appears in today"s Journal of the American Medical Association. Prescribing narcotics for pain in emergency rooms rose during the study, from 23 percent of those complaining of pain in 1993 to 37 percent in 2005.
The increase coincided with changing attitudes among doctors who now regard pain management as a key to healing. Doctors in accredited hospitals must ask patients about pain, just as they monitor vital signs such as temperature and pulse.
Even with the increase, the racial gap endured. Linda Simoni-Wastila of the University of Maryland at Baltimore's School of Pharmacy said the race-gap finding may reveal some doctors' suspicions that minority patients could be drug abusers lying about pain to get narcotics.
The irony, she said, is that blacks are the least likely group to abuse prescription drugs. Hispanics are becoming as likely as whites to abuse prescription opioids and stimulants, according to her research. She was not involved in the current study.
In the study, opioid narcotics were prescribed in 31 percent of the pain-related visits involving whites, 28 percent for Asians, 24 percent for Hispanics and 23 percent for blacks.
Minorities were slightly more likely than whites to get aspirin, ibuprofen and similar drugs for pain.
The study's authors said doctors may be less likely to see signs of painkiller abuse in white patients, or they may be undertreating pain in minority patients.
Patient behavior may play a role, Dr. Pletcher said. Minority patients "may be less likely to keep complaining about their pain or feel they deserve good pain control," he said.
Stricter protocols for prescribing narcotics may help close the gap.
A New York hospital recently studied its emergency patients and found no racial disparity in narcotics prescribed for broken bones. Montefiore Medical Center aggressively treats pain and is developing protocols for painkillers that dictate initial dosages and times to check with patients to determine whether they need more pain medicine, said Dr. David Esses, emergency department associate director at Montefiore.
Such standards may eliminate racial disparities, Dr. Esses said.
source: The Washington Times
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